Agenda

Wednesday, September 10

3:00-6:00

Registration / Opening Night Reception

Thursday, September 11

7:00-8:00

Breakfast

8:00-8:10

Don Fitzgerald, Roche Colorado Corporation

Welcome

8:10-8:15

Ralph DiLibero, Roche Colorado Corporation

Housekeeping

Peptides in the Clinic

8:15-9:00

Angelika Fretzen, Ironwood Pharmaceuticals

Linaclotide, a First-in-Class Guanylate Cyclase C Agonist in Development for the Treatment of Irritable Bowel Syndrome with Constipation and Chronic Constipation

9:00-9:45

Bruce Morimoto, Allon Therapeutics

Neuroprotection by AL-108; A Case Study for Development of a CNS-Active Peptide as a Treatment for Alzheimer’s Disease

9:45-10:00

Coffee Break

10:00-10:45

Richard Duke, Apoplogic Pharmaceuticals

Breceptin: Pre-Clinical Data and Clinical Development Plans for a Peptide-Based Bradykinin Antagonist in Small Cell Lung Cancer

10:45-11:30

Soren Kjareluff, Novozymes

NZ2114 Plectasin, a New Antibiotic for Treatment of Resistant Gram Positive Bacterial Infections

11:30-11:50

Panel Discussion

11:50-1:00

Lunch

Emerging Technologies

1:00-1:45

Paul Wentworth, Scripps / Oxford

A Chemical Link Between Inflammation and Protein Misfolding Diseases

1:45-2:30

Richard Dimarchi, Indiana University

The Emergence of Chemical Biotechnology and It’s Application to Optimization of Endocrine Hormones

2:30-3:00

Coffee Break

3:00-3:45

Gunnar Kaufmann, Scripps Research Institute

Bacterial Quorum Sensing as Target for Anti-Infective Therapy

3:45-4:30

Soumitra Ghosh, Amylin Pharmaceuticals

Integrated Neurohormonal Therapy for Obesity

4:30-4:50

Panel Discussion

6:00-10:00

Dinner at Red Lion Restaurant

Meienhofer Award

Presented by

John Tayer, Roche Colorado

Waleed Danho, Hoffmann-La Roche

Friday, September 12

7:00-8:00

Breakfast

Analytical and Biophysical Methods

8:00-8:45

John H. A. Amery, Pfizer

An Industry Perspective on the Use of Bioassays for Synthetic Peptide and Nucleotide Pharmaceuticals

8:45-9:30

Ted Randolph, University of Colorado

Conformational and Colloidal Contributions to Stability against Aggregation of Proteins

9:30-10:00

Coffee Break

Synthetic Methodology

10:00-10:45

Rashia Turner, University of Califonia Santa Cruz

Using Click Chemistry to Synthesize and Study the Relative Permeabilities of Cyclic Peptides and Their Linear Precursors

10:45-11:30

Robert P. Hammer, Louisiana State University

Amino Acid Analogues in the Design of Functional Peptide Mimics

11:30-11:50

Panel Discussion

11:50-1:00

Lunch

1:00-1:45

Chris Roberts, Roche Colorado Corporation

Development and Scale-Up of an MC-4 Agonist

Peptides in the Clinic 2

1:45-2:30

Les Mirand, Amgen Pharmaceuticals

Identification of Potent, Selective and Metabolically Stable Peptide Antagonists to the Calcitonin Gege-Related Peptide (CGRP) Receptor

2:30-3:00

Coffee Break

3:00-3:45

Claudio Mapelli, Bristol-Myers Squibb

A novel Class of 11-MER Peptide Agonist of the GLP-1 Receptor

3:45-4:30

Christian Elling, 7TM Pharma

Development of Y2 and Y4 GI-Tract Satiety Signals as Anti-Obesity Agents

4:30-4:50

Panel Discussion

5:00-8:00

Cocktail Reception and Poster Session

Presenting Sponsor

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